Effect of Endogamy and Consanguinity on the Development of Labial Venous Malformations in Area of Tlemcen (West Algeria)

Background: Vascular malformation is extremely rare, yet has a profound impact on quality of life, aesthetic and functional disorders. Aim: To show that endogamy and consanguinity may represent risk factors for labial venous malformation (LVM) development. Materials and Methodology: Among the 18093 scrutinized families on a 20 years back period from marriage registers, five families with a child presenting LVM were recruited from two geographic areas, one highly endogamous (Nedroma), the other slightly endogamous (Maghnia). These families were recruited for a retrospective descriptive essay at the Pathology and Oral Surgery Department of Tlemcen University Hospital Center (north-west of Algeria). Results: Four cases of LVM were from the Nedroma region, the fifth one from the Maghnia region. High consanguinity level was registered in patient families from Nedroma. On the other hand, the blood group O frequency was slightly higher compared to that of the blood group non-O. Conclusions: The present study suggests that consanguinity could beget LVM and that endogamy could increase its prevalence. The postulated association between this genetic disease and the OO genotype seems to be not confirmed. Therefore, it would be interesting to seek the SNP markers in this region.